Supplementary information regarding Transtympanic Gentamicin

Timothy C. Hain, MD

Last edited: 8/01. Please read our disclaimer.

Local anesthesia for TTG (or myringotamy)

Delivery systems for gentamicin

At the present writing, it doesn't seem to matter what delivery system is used to administer gentamicin. The cheapest approach appears to be the simple needle injection method. The Silverstein "Micro-Wick" requires a tympanostomy tube. The Microcatheter pump also requires a more invasive approach.

Dosing Regimen

For weekly injections, concentrations of 20 to 40 mg/ml are made up, buffered with bicarbonate, and injected so as to fill the middle ear. Between one and 6 injections are administered, typically once/week.

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