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Familial Hemiplegic Migraine.

This disorder is an autosomal domininant condition characterized by migraine, hemiparesis, and in some families, progressive cerebellar atrophy. It is associated with a mutation in the a-1a subunit gene for calcium channels. Four different missence mutations have been identified. Mutations in this subunit have also been identified in one of the episodic ataxias, and in one of the spinocerebellar atrophies (SCA-6).