Cogan's Syndrome

Last update: 2/2003. Please read our disclaimer.

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Timothy C. Hain, MD

Cogans syndrome is defined as nonsyphilitic interstitial keratitis (an inflammation of the eye) and bilateral audiovestibular deficits (hearing problems and dizziness). There is generally a brief episode of inflammatory eye disease (interstitial keratitis) followed by bilateral audiovestibular symptoms. The symptoms typically progressively deteriorate within days. While the ESR, WBC, C-reactive protein test may be abnormal and there may be thrombocytosis or anemia, none of these findings are reliable indicators of the disease. A slit-lamp examination is essential. Recent work has suggested that high-resolution MRI and antibodies to inner ear antigens may be helpful. Cogans children can occur in children, and is particularly difficult to recognize in that situation (Massinger and Keilmann, 2003).

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See also: Autoimmune Inner Ear Disease